histopathology of ppr

Necropsy and histopathology A total of seven dead goats were collected from seven PPR-suspected flocks and routine necropsy was performed in the Department of Pathology. Reduction of Ppr expression to very low levels prevented mammary gland development. Learn more about Institutional subscriptions, Banyard AC, Parida S, Batten C, Oura C, Kwiatek O, Libeau G (2010) Global distribution of peste des petits ruminants virus and prospects for improved diagnosis and control. Subscription will auto renew annually. J Vet Med B 51:68–71, Muniraju M, Munir M, Parthiban AR, Banyard AC, Bao J, Wang Z, Ayebazibwe C, Ayelet G, El Harrak M, Mahapatra M, Libeau G, Batten C, Parida S (2014) Molecular evolution of peste des petits ruminants virus. At 150 mg/kg/day, slightly greater outer hair cell loss noted than control group. https://doi.org/10.1007/s00705-019-04269-y, DOI: https://doi.org/10.1007/s00705-019-04269-y, Over 10 million scientific documents at your fingertips. Histopathology of natural cases of PPR, characteristics, lesions and changes occurring during the disease. Laboratory diagnosis of PPR a. In this report, we describe a severe PPR outbreak in a zoo herd of Nubian ibex (Capra nubiana), causing the deaths of 2/3 of the herd. Proceedings of the International Workshop, September 24-26, 1980, IITA Ibadan, Nigeria, pp: 24-26. 4.6 Histopathology. An outbreak of peste des petits ruminants (PPR) in camels in the Sudan ... Histopathology Histopathologically, the bronchioles showed degeneration and denudation of the epithelium and peribronchial infiltration of mononuclear cell (Fig. Histopathology of natural cases of PPR, Characteristic lesions and changes occurring during the disease peste des petits ruminants (PPR) in sheep and goats. The tissue that is studied comes from a biopsy or surgical procedure whereby a sample of the suspect tissue is selected and sent to the laboratory. PPR proteins function in organelles to target specific transcripts and are involved in plant development and growth. This is likely due to variations in At the end of the outbreak, blood can be collected for serological diagnosis. 13. In both species, significant levels of virus were detected in the lymph nodes, lymphoid tissues and digestive tract at 6 dpi. J Gen Virol 91:2885–2897. A tentative diagnosis of PPR can be made based on clinical signs, but this ... • Set of tissues for histopathology should be placed in 10% neutral buffered formalin Our primary purpose is to publish advances in pathology, in particular those applicable to clinical practice and contributing to the better understanding of human disease. By continuing you agree to the use of cookies. PPR is a disease of high morbidity and mortality that affect small ruminants reared by poor and marginal farmers of India. Proceedings of the International workshop held at IITA Ibadan, Nigeria, 24-26 September. Key words: goats, histopathology, immunomodulation, Nigella Sativa, PPR. D.H Hill (eds) ILCA Addis Ababa. 5. Oran Erster. Confirmatory tests include histopathology, polymerase chain reaction (PCR), virus isolation (VI), and virus neutralization (VN). INTRODUCTION Peste des petits ruminants (PPR), is an acute, highly contagious and economically important transboundary viral disease of sheep and goats associated with high morbidity and mortality (Balamurugan et al., 2014). Accessed May 2019, Singh RP, Saravanan P, Sreenivasa BP, Singh RK, Bandyopadhyay SK (2004) Prevalence and distribution of peste des petits ruminants virus infection in small ruminants in India. The specialist doctor who does the examination under the microscope is called a pathologist. Looking for online definition of PPR or what PPR stands for? The Endocrine Pancreas 3. Isr J Vet Med 49:49–59, Furley CW, Taylor WP, Obi TU (1987) An outbreak of peste des petits ruminants in a zoological collection. The endocrine cells of the pancreas are localized in the islets of Langerhans and constitute only 2% of the mass of the pancreas. https://doi.org/10.1371/journal.pone.0087145, Article  Emerg Infect Dis 21:2230–2234, Shatar M, Khanui B, Purevtseren D, Khishgee B, Loitsch A, Unger H, Settypalli TBK, Cattoli G, Damdinjav B, Dundon WG (2017) First genetic characterization of peste des petits ruminants virus from Mongolia. Pustular lesions usually have a … Following the first description of PPR it was postulated that the causal agent was a variant strain of rinderpest adapted to small ruminants (Mornet et al., 1956).This was confirmed by the present knowledge on the epidemiology of the two diseases which occur separately … The alveolar septa was congested and PPR is defined as Preyer's pinna reflex rarely. In the regions where PPR occurs in an epizootic form it may have dramatic consequences for animal owners due to high mortality rates. Springer-Verlag Berlin Heidelberg, pp 69–93, Abu Elzein EME, Housawi FM, Bashareek Y, Gameel AA, Al-Afaleq AI, Anderson E (2004) Severe PPR infection in gazelles kept under semi-free range conditions. PubMed  However, in countries that are PPR-free, a single serum sample (taken at least a week after the onset of clinical signs) may be diagnostic. The PWG will consist of7 10 pathologists Histopathology Histopathology refers to the microscopic examination of various forms of human tissue. Mesenteric lymph node -PCR PPR ha s become endemic in the country and Outbreak, PPR, Goats, ELISA, RT-PCR. The tissue samples of lips, trachea, lungs, spleen, lymph node, intestine, kidney, heart, spleen and liver were 4). Presumptive diagnosis of the disease was done on the basis of history, clinical signs, mortality pattern, postmortem and histopathological findin gs. . It is generally accepted that pathology peer review (PPR) is an important procedure to verify and improve the accuracy and quality of histopathology data generated by the study pathologist in toxicological studies of xenobiotics including pharmaceuticals and agrochemicals with experimental animals. Histopathological examination of tissues starts with surgery, biopsy or autopsy. Looking for online definition of PPR or what PPR stands for? Histopathological assessment of PPRV-infected tissues demonstrates many of the. Histopathology combined with immunohistochemical staining (e.g. It was first reported in Cote d’Ivoire (the Ivory Coast) in 1942 and subsequently in other parts of West Africa. Peste des petits ruminants (PPR) is an acute or subacute viral disease of goats and sheep characterized by fever, necrotic stomatitis, gastroenteritis, pneumonia, and sometimes death. It is closely related to Rinderpest, measles, canine distemper and morbilliviruses of marine mammals and is the most economically important viral disease of small ruminants [1-3]. For some diseases, th… A tentative diagnosis of PPR can be made based on clinical signs, but this diagnosis is ... • Set of tissues for histopathology should be placed in 10% neutral buffered formalin Mesenteric lymph node -PCR PPR ha s become endemic in the country and Outbreak, PPR, Goats, ELISA, RT-PCR. Correspondence to Discussion. Fragments of organs collected for histopathology are placed in 10% formalin. Copyright © 1998 Elsevier Science B.V. All rights reserved. PPR virus isolates differ in their pathogenicity for each host, with some strains resulting in more disease in sheep than goats. The course of the disease may be peracute acute or chronic, however the virus does not persist. The diagnosis of PPR virus infection both in natural outbreak and experimental cases were based on clinical signs, gross pathology, histopathology and ELISA test for confirmation of the PPR virus. Specifically, in clinical medicine, histopathology refers to a biopsy or surgical sample examination by a pathologist. • Histopathology specimens are a vital in patient care. OVERVIEW OF HISTOPATHOLOGYBYSEEMA DEROTRANIEE TECHNOLOGIST 2. Pathological and molecular characterisation of peste des petits ruminants in Nubian ibex (Capra nubiana) in Israel. Epidemiol Infect 138:1211–1214, Mahapatra M, Sayalel K, Muniraju M, Eblate E, Fyumagwa R, Shilinde L, Mdaki M, Keyyu J, Parida S, Kock R (2015) Spillover of Peste des petits ruminants virus from domestic to wild ruminants in the serengeti ecosystem, Tanzania. Whenever possible, paired sera should be taken rather than single samples. Copyright © 2020 Elsevier B.V. or its licensors or contributors. Present address: Central Virology Laboratory, Israeli Ministry of Health, Sheba Medical Center, 5266202, Ramat Gan, Israel. All the outbreaks recorded revealed no sex differences but the age of susceptibility was seen much in young ones and death was more noted in them. immunoperoxidase) is then performed with focus on detection of multinucleated giant cells. Arch Virol 164, 1997–2003 (2019). histopathology is the only way to diagnose infections caused by L. loboi or Rhinosporidium seeberi [Figure 2] as cultivation techniques have to date been unsuccessful. Oral lesions and pulmonary lesions were rare. Presumptive diagnosis of the disease was done on the basis of history, clinical signs, mortality pattern, postmortem and histopathological findin gs. PPR is listed in the World's largest and most authoritative dictionary database of abbreviations and acronyms The Free Dictionary Accepted: 29 June 2017 • They not only establish tissue diagnosis, but are crucial in clinical management & provide important prognostic data. . Histology. Background. INTRODUCTION Peste des petits ruminants (PPR), is an acute, highly contagious and economically important transboundary viral disease of sheep and goats associated with high morbidity and mortality (Balamurugan et al., 2014). https://doi.org/10.1016/S0921-4488(97)00095-3. Histopathology - Definition it is a branch of pathology which deals with the study of disease in a tissue section. No single pathognomonic lesion is found that would permit certain histopathologic diagnosis of HPS. Animal Front 4:14–20, Kinne J, Kreutzer R, Kreutzer M, Wernery U, Wohlsein P (2017) Peste des petits ruminants in Arabian wildlife. It is characterized bysudden onset of fever, oculonasal discharges,necrotic stomatitis, gastroenteritis and death. PPR is listed in the World's largest and most authoritative dictionary database of abbreviations and acronyms The Free Dictionary Since then, other attempts to reproduce the pathology associated with PPR have been performed under experimental conditions [13–16], however, results have varied considerably. the histopathology of samples from infected animals was consistent with those found in naturally infected animals. Peste des Petits Ruminants (PPR), also known as Goat Plague and Ovine Rinderpest, occurs in goats, sheep and related species. PPR and not in RP are crusting scabs along the lips and development of pneumonia in later stages of disease. J Comp Pathol 136:111–119, Libeau G, Diallo A, Parida S (2014) Evolutionary genetics underlying the spread of peste des petits ruminants virus. 226 patients with rosacea, which included 52 patients with the erythematotelangiectatic rosacea (ETR) and 174 patients with the papulopustular rosacea (PPR) subtype. Menu Search ... gross necropsy, and histopathology... s.c, 28 days No effect on Preyer pinna reflex or AC cochlear potential. PPR is often rendered more severe by secondary bacterial infections, concomitant helminthiasis, Aims and Scope. In both species, significant levels of virus were detected in the lymph nodes, lymphoid tissues and digestive tract at 6 dpi. Withsome strains of the virus, however, the diseasemay be mild with low mortality frominfection. Rev Sci Tech 23:807–819, Truong T, Boshra H, Embury-Hyatt C, Nfon C, Gerdts V, Tikoo S, Babiuk LA, Kara P, Chetty T, Mather A, Wallace DB, Babiuk S (2014) Peste des petits ruminants virus tissue tropism and pathogenesis in sheep and goats following experimental infection. However, ... Fragments of organs collected for histopathology are placed in 10% formalin. PPR stands for Preyer's pinna reflex. Pathology Patterns Reviews is a historical title linked to American Journal of Clinical Pathology, publishing within the field of pathology. This study revealed peculiar findings such as severe affection of respiratory system with mild involvement of alimentary system that was seen to be rare and exclusively to Indian outbreaks of PPR. PPR in sheep and goats - a review. 6: Libeau, G., A. Histopathology of natural cases of PPR, characteristic lesions and changes occurring during the disease peste des petits ruminants (PPR) in sheep and goats. PPR is an acute highly contagious viral disease of goats, less commonly sheep and closely related wild bovidae, and is clinically mimics cattle plague, ... For histopathology slices of lymph node, spleen, tonsils, and mucosal lesions are collected in 10 % formalin saline for. Papulopustular rosacea (PPR) is the classic presentation of rosacea. The disease has been declared a target for global eradication. PubMed Central  The histopathology, IHC, and quantitative RT-PCR results from both sheep and goats also provide some insight into the disease progression of PPR in small ruminants. INTRODUCTION Peste des petits ruminants (PPR), is an acute, highly contagious and economically important transboundary viral disease of sheep and goats associated with high morbidity and mortality (Balamurugan et al., 2014). Histology revealed necrohemorrhagic enteritis and abomasitis with myriad nuclear and cytoplasmic viral inclusion bodies. Papulopustular rosacea (PPR) is the classic presentation of rosacea. Author information: (1)Department of Radiology, University of Cambridge, Cambridge, United Kingdom. PPR stands for Preyer's pinna reflex. Recognition of PPR as a problem has increased in the 1990s, partly as a result of surveillance activities of the global rinderpest eradication programme (GREP), but also because of the capacity of the infection to invade disease-free countries. The histopathological aspect of the infection in various organs has been studied in correlation with the clinical signs and symptoms from materials collected in 10 different outbreaks of PPR in goats. The clinical onset was acute with morbid animals exhibiting lethargy and watery-to-bloody diarrhea and death usually within 48 h. The most consistent gross pathologic findings were hemorrhagic abomasitis and enteritis. Department has modern histopathology, cytopathology, haematology and service laboratories for catering the needs of Mahatma Gandhi Hospital attached to the medical college. Histopathology is an international journal intended to be of practical value to surgical and diagnostic histopathologists, and to investigators of human disease who employ histopathological methods. To achieve this it is important that the tissue must be prepared in such a Below is the link to the electronic supplementary material. Peste des petits ruminants (PPR) is a devastating disease that generally affects sheep and goats, mostly in Asia, the Middle East and Africa. Since then, other attempts to reproduce the pathology associated with PPR have been performed under experimental conditions [13–16], however, results have varied considerably. Ed. PPR is known as goat plaque and it is referred to as kata in Nigeria and as pseudo rinderpest (Otte, 1960; Rowland and Bourdin, 1970; Hamdy et al., 1976). Molecular examinations confirmed the diagnosis of PPR and determined that the causative agent belongs to lineage IV. affected animals were vaccinated against PPR. Peste des petits ruminants (PPR) is a highly contagious viral disease of goats and sheep. Vet Microbiol 22:341–352, Perl S, Alexander A, Yakobson B et al (1994) Peste des petits ruminants (PPR) of sheep in Israel. ... Fragments of organs collected for histopathology are placed in 10% formalin. 4. In tumors that showed a pPR, 27.1% were grade 1 tumors, 27.1% were grade 2 tumors, and 2.1% were grade 3 tumors (Table 5). Related Pages. Peste des petits ruminants (PPR) is an acute to sub-acute highly contagious and frequently fatal viral disease of goats and sheep and wild small ruminants caused by a virus in the genus morbilivirus, family paramyxoviridae. HistoPATHOLOGY 1. : Muhammad Munir. The Morbilli viruses responsible for Rinderpest in cattle and Peste des petits ruminants (PPR) in sheep and goats, are important pathogens of domestic ruminants. Peste des petits ruminants (PPR) is an acute or subacute viral disease of goats and sheep characterized by fever, necrotic stomatitis, gastroenteritis, pneumonia, and sometimes death. It is caused by a morbillivirus in the family Paramyxoviridae. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Histopathological study of a natural outbreak of Peste des petits ruminants in goats of Tamilnadu. Histopathology combined with immunohistochemical staining (e.g. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Tax calculation will be finalised during checkout. Histopathology of natural cases of PPR, Characteristic lesions and changes occurring during the disease peste des petits ruminants (PPR) in sheep and goats. pathologyevaluation (necropsyand histopathology), pathologypeerreview, and ... majordiscrepanciesorno resolution at the PPR, then a PWG maybe convened. Peste des petits ruminants (PPR) in sheep and goats. Peste des petits ruminants virus. PubMed Google Scholar. Grossing is an art A knowledge of what needs be taken for microscopic study is crucial for final diagnosis. Rinderpest, or cattle plague, is an acute, highlycontagious viral disease of wild and domesticatedruminants and pigs. This is likely due to variations in affected animals were vaccinated against PPR. 14. Aims and Scope; Submitting your Manuscript 2.1 Submission Checklist 2.2 Article Preparation Support 2.3 Review Process 2.4 Manuscript Structure 2.5 Graphical Abstract 2.6 Submission of a Revised Version; Post-acceptance; 1. The first article covered the inconsistencies and controversies that have prevailed during the last three decades regarding the term ‘raw data’ as applied The disease has been declared a target for global eradication. Berkowitz, A., Avni-Magen, N., Bouznach, A. et al. However, acute rinderpest can occasionally be seen in small ruminants. Asaf Berkowitz and Oran Erster contributed equally to this work. Emerg Infec Dis 15:299–301, Article  The frequency of each histopathological finding was compared between subtypes. In fact, the incipient stages of ARDS can create a picture of pulmonary edema similar to HPS. Vet Microbiol 197:137–141. PubMed  It is good practice to collect blood for serological diagnosis at all stages, but particularly later in the outbreak. Arch Virol 162:3157–3160. Key words: goats, histopathology, immunomodulation, Nigella Sativa, PPR. Results: … the histopathology of samples from infected animals was consistent with those found in naturally infected animals. As most of the flocks are unvaccinated against PPR virus, so an economical antibody-based test may serve the purpose of PPR diagnosis. Google Scholar, Hoffmann B, Wiesner H, Maltzan J, Mustefa R, Eschbaumer M, Arif FA, Beer M (2012) Fatalities in wild goats in kurdistan associated with peste des petits ruminants virus. The histopathology, IHC, and quantitative RT-PCR results from both sheep and goats also provide some insight into the disease progression of PPR in small ruminants. The histopathological study revealed extensive involvement of lungs, lymph nodes, spleen, intestine, liver, in descending order of severity. Printer friendly. A less‐severe reduction in Ppr expression permitted progression of mammary gland development beyond the induction stage, but the nipples of these mice were dramatically smaller than those of controls, with altered epidermis and connective tissue. histopathology. PPR can be made on clinical signs, but this diagnosis is considered provisional until laboratory confirmation is ... histopathology are placed in 10% neutral buffered formalin. https://doi.org/10.1016/j.vetmic.2016.11.006, OIE: The OIE official info http://www.oie.int/fr/sante-animale-dans-le-monde/portail-ppr/. (PMID: 25418782), Taylor WP, Albusaidy S, Barrett T (1990) The Epidemiology of peste-des-petits-ruminants in the sultanate of Oman. Confirmatory tests include histopathology, polymerase chain reaction (PCR), virus isolation (VI), and virus neutralization (VN). Peste des petits ruminants (PPR) is a devastating disease that generally affects sheep and goats, mostly in Asia, the Middle East and Africa. The disease has been declared a target for global eradication. Background: The pentatricopeptide repeat (PPR) gene family, which contains multiple 35-amino acid repeats, constitutes one of the largest gene families in plants. Gross pathological changes were recorded. Majority were grade 2 tumors out of which 81% showed pPR and 18.5% showed pCR. The tissue undergoes a series of steps before it reaches the examiners desk to be thoroughly examined microscopically to arrive at a particular diagnosis. However, the total picture is rather distinctive. In PPR, papules usually contain a prominent perivascular and perifollicular inflammatory infiltrate in the superficial and mid-dermis consisting of lymphocytes, neutrophils, and plasma cells. Proceedings of the International Workshop, September 24-26, 1980, IITA Ibadan, Nigeria, pp: 24-26. https://doi.org/10.1099/vir.0.025841-0, Article  Background: The pentatricopeptide repeat (PPR) gene family, which contains multiple 35-amino acid repeats, constitutes one of the largest gene families in plants. 18. endocrine pancreas 1. The clinical picture may vary and diarrhea may not be a prominent sign. It was first reported in Cote d’Ivoire (the Ivory Coast) in 1942 and subsequently in other parts of West Africa. Also, if there isa high profile chemical, then a PWG maybe conducted in place of a PPR. CAS  PLoS One 9:e87145. PPR and not in RP are crusting scabs along the lips and development of pneumonia in later stages of disease. Vet Rec 121:443–447, Kwiatek O, Minet C, Grillet C, Hurard C, Carlsson E, Karimov B, Albina E, Diallo A (2007) Libeau G (2007) peste des petits ruminants (PPR) outbreak in Tajikistan. Further molecular examination showed that the virus belongs to the Asian clade of lineage IV and is closely related to a virus described in Turkey. It is caused by PPR virus, a morbillivirus of the Division of Pathology, Kimron Veterinary Institute, Bet Dagan, 50250, Israel, Division of virology, Kimron Veterinary Institute, 50250, Bet Dagan, Israel, Orly Friedgut, Velizar Bombarov, Marisol Guini-Rubinstein, Yehuda Stram, Avi Eldar & Oran Erster, Biblical zoo of Jerusalem, Derech Aharon Shulov 3, Jerusalem, Israel, Veterinary Clinic, 9 Meginay Hagalil Street, Rehovot, Israel, You can also search for this author in Emerg Infect Dis 20:2023–33. This article deals with the first exclusive outbreak of PPR in goats in a mixed population that occurred in the southern districts of Tamilnadu, India. The histopathology and immunohistochemistry of most of the target tissues (intestines, tongue, lungs and lymph nodes) showed positive signal for PPR … Google Scholar, Wang Z, Bao J, Wu X, Liu Y, Li L, Liu C, Suo L, Xie Z, Zhao W, Zhang W, Yang N, Li J, Wang S, Wang J (2009) Peste des petits ruminants virus in Tibet, China. It is then processed and cut into very thin layers (called sections), stained, and examined under microscopes to characterize the details of the cells in the tissue. Google Scholar, Fakri F, Embarki T, Parida S, Bamouh Z, Jazouli M, Mahapatra M, Tadlaoui K, Fassi-Fihri O, Richardson CD, Elharrak M (2016) Re-emergence of peste des petits ruminants virus in 2015 in morocco: molecular characterization and experimental infection in alpine goats. https://doi.org/10.3201/eid2012.140684 PPR is regarded as the most economically important viral disease of small ruminants particularly goats in areas where these animals are intensively reared. Out of the 21 cases of grade 1 tumors 66.7% showed pPR and 33% showed pCR. Since no studies with live animals were conducted in this work, an ethical approval was not required. Archives of Virology This is a preview of subscription content, log in to check access. Part of Springer Nature. This study was funded by internal resources of the Kimron Institute. Author Guidelines. Peste des petits ruminants (PPR) in sheep and goats. However, the function of PPR proteins in cotton is still unknown.

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